What is Tagrisso (osimertinib) for?
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Tagrisso (osimertinib) is a kinase inhibitor indicated for the treatment of patients with a specific type of lung cancer (metastatic epidermal growth factor receptor (EGFR) T790M mutation positive non-small cell lung cancer (NSCLC)):
as first-line treatment of patients whose tumours have EGFR exon 19 deletions or exon 21 L858R mutations.
as second line treatment of patients whose disease has progressed on or after EGFR TKI therapy1.
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How does Tagrisso (osimertinib) work?
The activity of the epidermal growth factor receptor (EGFR) normally controls growth and division of cells. In lung cancer cells, the EGFR is often overactive, causing uncontrolled division of cancer cells.
By blocking the EGFR, osimertinib helps to reduce the growth and spread of the cancer. Unlike most other tyrosine kinase inhibitors, Tagrisso (osimertinib) is active against cancer cells with the T790M mutation in the EGFR gene. Buy Tagrisso osimertinib Online at very affordable prices from epharmazone.com
Where has Tagrisso (osimertinib) been approved?
Tagrisso (osimertinib) has been approved for advanced or metastatic NSCLC in patients with epidermal growth factor receptor (EGFR) T790M mutation by the following regulatory agencies in the following regions:
- Food and Drug Administration (FDA), USA:
- November 13, 2015, with accelerated approval (second-line treatment)
- March 30, 2017, with regular approval (second-line treatment)
- April 18, 2018, as a first line treatment
- European Medical Agency (EMA), European Union:
- February 2, 2016 (second-line treatment)
- June 11, 2018 (first-line treatment)
- Therapeutic Goods Administration (TGA), Australia, August 3, 2016 (second line treatment)3
Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.
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How is Tagrisso (osimertinib) taken?
The standard dosage is:
- 80 mg orally once daily
Complete information about Tagrisso (osimertinib) dosage and administration can be found in the official prescribing information.
Note: Please consult with your treating doctor for personalised dosing.
Are there any known side effects or adverse reactions of Tagrisso (osimertinib)?
Common adverse reactions
The most common adverse reactions listed in the prescribing information include:
- dry skin
- nail toxicity
Serious adverse reactions
The serious adverse reactions listed in the prescribing information include1:
- interstitial lung disease (ILD)/pneumonitis
- heart rate disturbances (QTc Interval Prolongation)
- keratitis (inflammation of the cornea of the eye).
Use in a specific population
Tagrisso (osimertinib) can be fatal for a fetus, it is advised to avoid pregnancies during treatment and for 6 weeks after the final dose.
Men are advised to use effective contraception for 4 months, after the last dose. Do not breastfeed.
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information
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The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.
Remember, keep this and all other medicines out of the reach of children and away from pets, never share your medicines with others, and use this medication only for the indication prescribed.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.